Jeffrey Chuang (Boston College)-Identifying Hidden Functional Elements in Coding Regions
Mathematics - Colloquium
| Date & Time: |
Thursday, February 16, 2012 4:15 PM-5:15 PM |
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| Suggested Audiences: | College, Adult | |
| Location: Find Local Food & Accommodations |
WPI: Gateway Park 1002 60-68 Prescott Street Worcester, MA 01609 |
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| Description: | ABSTRACT: It has been increasingly appreciated that protein-coding DNA sequences harbor hidden regulatory sequences in addition to encoding for protein. These may include motifs that act at the DNA level, such as transcription factor binding sites, as well as motifs that act at the RNA level, such as microRNA-RNA binding sites. Detecting unusually overrepresented or conserved motifs has been algorithmically challenging because of interference by constraints at the protein level. I will present methods we have developed to efficiently calculate motifs of unusual conservation or overrepresentation in coding regions. Our studies indicate that hidden regulatory motifs are prevalent throughout eukaryotic and prokaryotic genomes. Additionally, I will present experimental results on whether coding regions can contain larger regulatory sequences. Our zebrafish studies indicate that vertebrate developmental genes contain large numbers of transcriptional enhancers, showing that proteins are malleable enough that even complex secondary functions can evolve in the same location. This colloquium is jointly sponsored by the Departments of Biology & Biotechnology, and Mathematical Sciences. |
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| More Information: |
E-mail:
ma-chair@wpi.edu
Entered by: WPI: Mathematical Sciences Department |
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Created: February 9, 2012 at 9:30 AM
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