Heiko Enderling (Center of Cancer Systems Biology, Tufts University School of Medicine)-Cancer stem cells in solid tumors
Mathematics - Colloquium
Friday, April 6, 2012
11:00 AM-12:00 PM
ABSTRACT: The cancer stem cell hypothesis postulates that only a subpopulation of cancer cells in a tumor is capable of initiating, sustaining and re-initiating tumors, leaving the bulk of the population being non-stem cancer cells that lack tumor initiation and progression potential. With these two phenotypically distinct populations interacting with each other, the emerging tumor population can exhibit various non-linear growth kinetics. An environmentally independent early dormant state is an inevitable early tumor progression bottleneck for a large range of biologically realistic cell kinetic parameters. When intrinsic cell kinetics combine in unexpected manner, escape to tumor progression occurs as morphologically distinct self-metastatic expansion of multiple self-limited tumor clones.
Suggested Audiences: Adult, College
Last Modified: February 13, 2012 at 11:54 AM