Heiko Enderling (Center of Cancer Systems Biology, Tufts University School of Medicine)-Cancer stem cells in solid tumors

Mathematics - Colloquium

Friday, April 6, 2012
11:00 AM-12:00 PM

Stratton Hall

ABSTRACT: The cancer stem cell hypothesis postulates that only a subpopulation of cancer cells in a tumor is capable of initiating, sustaining and re-initiating tumors, leaving the bulk of the population being non-stem cancer cells that lack tumor initiation and progression potential. With these two phenotypically distinct populations interacting with each other, the emerging tumor population can exhibit various non-linear growth kinetics. An environmentally independent early dormant state is an inevitable early tumor progression bottleneck for a large range of biologically realistic cell kinetic parameters. When intrinsic cell kinetics combine in unexpected manner, escape to tumor progression occurs as morphologically distinct self-metastatic expansion of multiple self-limited tumor clones.

Suggested Audiences: Adult, College

E-mail: ma-chair@wpi.edu

Last Modified: February 13, 2012 at 11:54 AM

Add/Suggest Event | Edit Your Events | RSS

Powered by the Social Web - Bringing people together through Events, Places, & Common Interests