## Math Bio Seminar Series-Sam Isaacson (Boston University)-The Influence of Spatial Variation in Chromatin Density on the Time to Find DNA Binding Sites

Mathematics - Lecture/Discussion

Tuesday, October 8, 2013

4:00 PM-5:00 PM

Stratton Hall

304

ABSTRACT: We will describe our recent work investigating how volume exclusion due to the spatially varying density of DNA in the nucleus influences the time required for proteins to find DNA binding sites. A lattice master equation model will be derived to approximate the drift-diffusion process the protein undergoes as it searches for the binding site. Detailed three-dimensional simulations of the protein's search process will then be constructed using several different types of high-resolution imaging of the interior of mammalian cell nuclei. Using matched asymptotic expansions, we will develop a mathematical theory to explain our observed simulation results.

Suggested Audiences:
Adult, College

E-mail:
ma-chair@wpi.edu

Last Modified: September 18, 2013 at 8:58 AM

## Math Bio Seminar Series-Sam Isaacson (Boston University)-The Influence of Spatial Variation in Chromatin Density on the Time to Find DNA Binding Sites

Mathematics - Lecture/Discussion

Tuesday, October 8, 2013

4:00 PM-5:00 PM

Stratton Hall

304

ABSTRACT: We will describe our recent work investigating how volume exclusion due to the spatially varying density of DNA in the nucleus influences the time required for proteins to find DNA binding sites. A lattice master equation model will be derived to approximate the drift-diffusion process the protein undergoes as it searches for the binding site. Detailed three-dimensional simulations of the protein's search process will then be constructed using several different types of high-resolution imaging of the interior of mammalian cell nuclei. Using matched asymptotic expansions, we will develop a mathematical theory to explain our observed simulation results.

Suggested Audiences: Adult, College

E-mail: ma-chair@wpi.edu

Last Modified: September 18, 2013 at 8:58 AM