Mathematics - Lecture/Discussion
Tuesday, October 8, 2013
4:00 PM-5:00 PM
ABSTRACT: We will describe our recent work investigating how volume exclusion due to the spatially varying density of DNA in the nucleus influences the time required for proteins to find DNA binding sites. A lattice master equation model will be derived to approximate the drift-diffusion process the protein undergoes as it searches for the binding site. Detailed three-dimensional simulations of the protein's search process will then be constructed using several different types of high-resolution imaging of the interior of mammalian cell nuclei. Using matched asymptotic expansions, we will develop a mathematical theory to explain our observed simulation results.
Suggested Audiences: Adult, College
Last Modified: September 18, 2013 at 8:58 AM