Science / Technology - Lecture/Discussion - WPI Only
Wednesday, February 12, 2014
4:00 PM-5:00 PM
Modern imaging technologies, especially fluorescence microscopy, have revolutionized biological research, enabling in vivo, real-time studies at the cellular or sub-cellular level. The recent emergence of super-resolution imaging techniques, which surpass the optical diffraction limit, has advanced fluorescence imaging with near-molecular-scale resolution. Amongst super-resolution imaging techniques, the single-molecule-based stochastic optical reconstruction microscopy (STORM) relies on stochastic activation and sequential localization of individual fluorescent molecules which decorate an imaging target. While STORM has enabled the study of biological organizations and processes at the nanoscale in molecular and cellular systems, it is still incapable of bridging the gap in our understanding between the microscopic molecular and cellular interactions and the large-scale tissue and organ functions and activities. This talk will address the challenges in super-resolution fluorescence microscopy and describe several new biophotonic methods that provide solutions for imaging whole-cells and tissues with nanometer-scale resolution.
Suggested Audiences: College
Last Modified: January 23, 2014 at 9:44 AM