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BBT/CBC Guest Speaker Seminar: Jonathan Gitlin, M.D.

Science / Technology - Lecture/Discussion - WPI Only

Wednesday, April 10, 2013
12:00 PM-1:00 PM

Gateway Park
GP1002

DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY
and
DEPARTMENT OF BIOLOGY AND BIOTECHNOLOGY

Present

Aceruloplasminemia

Jonathan D. Gitlin, M.D.
Senior Scientist
Marine Biological Laboratories
Woods Hole, MA

Hosted By:
Dr. José Argüello
Dr. Jagan Srinivasan

Abstract
Ceruloplasmin is a member of the multicopper oxidase family of enzymes, which utilize the electron chemistry of bound copper ions to couple substrate oxidation with the four-electron reduction of dioxygen. Ceruloplasmin plays an essential role in human iron metabolism and inherited loss of function results in a progressive neurodegenerative disease termed aceruloplasminemia. In this seminar we will examine the mechanisms of copper incorporation into newly synthesized ceruloplasmin and discuss new insights into this process from the study of affected patients. The data provide a useful heuristic paradigm for understanding the mechanisms of metalloprotein synthesis.

Suggested Audiences: College, Adult

E-mail: cwebb@wpi.edu
Phone: 508-831-4111

Last Modified: April 5, 2013 at 2:17 PM

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