Science / Technology - Lecture/Discussion - WPI Only
Wednesday, November 7, 2012
4:00 PM-5:00 PM
Martin L. Yarmush, MD, PhD
Deparments of Biomedical and Chemical Engineering, Rutgers University, Piscataway, NJ
Center for Engineering in Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA
Recently there has been a paradigm shift in what is considered to be the therapeutic promise of mesenchymal stem cells (MSCs) in diseases of vital organs. Originally, research focused on MSCs as a source of regenerative cells by differentiation of transplanted cells into lost cell types. It is now clear that trophic modulation of inflammation, cell death, fibrosis, and tissue repair are the primary mechanisms of MSC therapy. This has been clarified in studies where delivery of growth factors, cytokines, and other signaling molecules secreted by MSCs is often sufficient to obtain the therapeutic effects. In this presentation, we provide a several examples of MSC therapy in disease models of vital organs using models of acute liver failure, acute kidney failure, and spinal cord injury. Critical gaps in our knowledge hampering experimental progress and clinical implementation are discussed.
Martin L. Yarmush is an internationally recognized bioengineer and biophysical chemist whose laboratory has been a pioneer and leader in multiple fields including: Applied Immunology and Biotechnology, Metabolic Engineering, BioMEMS and Bioanotechnology, and Tissue Engineering and Regenerative Medicine. Dr. Yarmush currently serves as the Paul and Mary Monroe Professor of Science and Engineering and Distinguished Professor of Biomedical Engineering at Rutgers University, and the Director of the Center for Engineering in Medicine at the Massachusetts General Hospital. Over the last 25 years, Dr. Yarmush has published more than 400 journal articles, has mentored over 120 postdoctoral fellows and graduate students, and has co-authored more than 40 patents and patent applications. A frequent invited speaker at major conferences and symposia, and winner of over 30 local and national awards, Dr. Yarmush’s research “pushes the envelope” on several healthcare technology frontiers through the use of state-of-the-art techniques that include microfabrication and nanotechnology, genomics and genetic engineering, advanced microscopic imaging, physiologic instrumentation, and numerical simulation. Dr. Yarmush received his Bachelor’s Degree from Yeshiva University, his MD degree from Yale University, and completed PhD work at The Rockefeller University in biopsysical chemistry and at MIT in chemical engineering.
Suggested Audiences: Adult, College
Last Modified: September 19, 2012 at 1:32 PM