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"New biomaterials, bioactive factor delivery systems, and cell microenvironments"

Science / Technology - Lecture/Discussion - WPI Only

Wednesday, January 30, 2013

Gateway Park
GP 1002

Tissue engineering holds the promise of producing functional biologic replacements to repair damaged and diseased tissues in the body. We use the complex signals that are implicated in tissue morphogenesis, repair, and homeostasis as a template for the development of innovative biomaterial systems for tissue regeneration. Through the precise temporal and spatial presentation of soluble bioactive factors, mechanical forces, and biomaterial physical and biochemical properties, we aspire to create biomaterials and microenvironments that regulate cell gene expression and new tissue formation. During todays talk, I will first discuss our efforts to control the delivery of siRNA. New three-dimensional macroscopic biopolymer scaffolds have been engineered retain and protect siRNA locally and release it in a sustained and tunable manner to prolong its gene silencing effect on transplanted cells and on cells directly at the site of interest for tissue engineering and cancer therapeutics. In the second half of the seminar, I will describe some of our recent work with high-density cell systems that has exciting clinical potential for treating diseases such as osteoarthritis.

Suggested Audiences: Elders, Adult, College, College, Adult, Elders

E-mail: bme-web@wpi.edu

Last Modified: January 16, 2013 at 2:33 PM

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