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SEMINAR - MEMS technologies for Mechanical Characterization of Adherent Cells, by Dr. Kidong Park, Postdoctoral Research Associate, University of Illinois at Urbana-Champaign

Education - Colloquium - WPI Only

Wednesday, January 30, 2013
11:00 AM-12:00 PM

Higgins Laboratories
HL102

MEMS (micro electromechanical system) are highly miniaturized electromechanical devices with a typical dimension
varying from a few to a few hundred µm. Due to its high level of precision and parallelism, MEMS technologies are
actively studied as break-through solutions to directly characterize various cellular properties, opening up a
new possibility to expand our understanding in various aspects of cellular metabolism and physiology.

Recent studies in the field of mechanobiology revealed that the mechanical properties of cell can be used as
effective parameters to represent cell status and complex cellular process. For instance, the mass or the growth
rate of a cell is directly related to the synthesis and accumulation rate of proteins, DNA, and other large
molecules inside the cell. Therefore, detailed characterization of mass and growth rate on a single cell level
can lead to deeper understanding in the intrinsic mechanism of cell growth. In addition, the cell stiffness and
the cell traction force are important parameters affecting cellular differentiation, cancer metastasis, and cell
spreading.

This talk will focus on the physical principle of resonant MEMS mass sensors with a uniform mass sensitivity and
their applications in the mechanical characterization of single adherent cells and other micro-scaled objects.
Besides, the structural analysis of hydrogel/cell hybrid bio-robots to extract the cell traction force of cardiac
myocytes will be presented.

Suggested Audiences: College

E-mail: prheaume@wpi.edu
Phone: 508-831-4875

Last Modified: January 23, 2013 at 12:36 PM

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